Synthetic modification of salinomycin: selective O-acylation and biological evaluation
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چکیده
منابع مشابه
Synthetic modification of salinomycin: selective O-acylation and biological evaluation.
Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl c...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2013
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c3cc45983g